PReS-FINAL-2165: Pharmacogenetic determinants of response to methotrexate in juvenile idiopathic arthritis
نویسندگان
چکیده
Introduction Juvenile idiopathic arthritis (JIA) is the most common arthritis disease of childhood and is an important cause of disability. Methotrexate (MTX) is the mainstay treatment in JIA. Unfortunately, 30-35% of patients fail to respond MTX, and the delay in identifying the optimal treatment at an early stage of disease can lead to longterm joint damage. Recent studies have evaluated comprehensively the effect of genetic variants in candidate genes involved in MTX pharmacokinetics and pharmacodynamics on the response to the medication in children with JIA. These studies seem to indicate that the most relevant variants to predict MTX response in JIA are those in ATIC, ITPA and SLC19A1 genes.
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